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A Different Approach to Sleep

  • Ramelteon (Rozerem) is an entirely new type of sleep agent, quite different from other prescription sleep aids currently available on the market. It acts on the melatonin receptors in the brain, inhibiting central nervous system activity.
  • It is considered the safest prescription sleep agent on the market at this time: It has not been shown to produce dependence or withdrawal symptoms, has shown no potential for abuse, and has not been linked with rebound insomnia upon abrupt discontinuation of treatment. Additionally, it has relatively few interactions with other drugs.
  • Unlike benzodiazepines, Ramelteon (Rozerem) does not bind to the GABA receptors in the brain, therefore it doesn't exhibit any anxiolytic, amnesic, or muscle relaxant effects.
  • Rozerem is primarily indicated for insomnia characterized by delayed sleep onset (difficulty initiating sleep).
  • It is considered to be a gentle, yet effective sleep agent. Daytime performance does not appear to be impaired to any significant degree after using this drug.
  • The recommended dose of Rozerem is 8 mg taken within 30 minutes of going to bed. Rozerem should not be taken immediately after a heavy or high-fat meal.

Please note:

  • Rozerem is contraindicated in severe liver disease, and should be administered with caution in moderate liver disease.
  • Rozerem should be administered with caution in persons taking medications such as fluconazole or ketoconazole, since it interferes with these agents.
  • Rozerem should not be administered in combination with the antidepressant Luvox (Fluvoxamine).


Disclaimer: The information on this page is correct to the best of our knowledge, but please note that it is not exhaustive and its accuracy is not guaranteed. For complete information on Rozerem, please consult a pharmacology monograph.


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