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Does It Work for Weight Loss ?

Nuphedrine is designed to suppress appetite and boost metabolism. This dietary supplement replaced the product known as 'Looking Trim/Ephedrine-P57'. As you may know, Ephedrine-containing products have been banned in the United States, as such 'Looking Trim/Ephedrine-P57' is no longer available. The replacement product Nuphedrine combines South African Hoodia (an appetite suppressant) with a patented substance named Advantra-Z, a plant extract with fat-burning properties supposedly similar to Ephedrine.

The active ingredient in Advantra-Z is Synephrine, which is obtained from the plant Citrus Aurantium (bitter orange). Advantra-Z is manufactured in several strengths: 5%, 6%, 10%, and 30%. The weight loss agent Nuphedrine contains the strongest concentration of Advantra-Z (30%,). In clinical studies, subjects taking Advantra at this strength have reportedly been proven to burn 500 additional calories per day, as compared to subjects not taking this substance (as per the official Nuphedrine website).

To their credit, the Nuphedrine website contains some rather impressive before and after pictures to attest to the efficacy of their product.

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Here's a list of the main ingredients:

  • South African Hoodia at a concentration of 20X: The active ingredient in Hoodia is the P-57 molecule, which acts on the hunger center in the brain to create a sensation of fullness. In clinical studies, subjects taking Hoodia at this concentration have reportedly been found to consume about 1000 cal less per day (as per the makers of Nuphedrine).

  • Advantra-Z at a concentration of 30% (active ingredient Synephrine) - with effects as discussed above.

  • Slimaluma - a plant extract initially used in India by the locals to suppress hunger. This is an appetite suppressant which, just like Hoodia, acts on the hunger center (hypothalamus) to suppress the hunger drive. However, when compared to Hoodia, Slimaluma has a shorter duration of action. If used before a meal, it should help you not overeat during that meal.

Side Effects:

According to the manufacturers, Nuphedrine does not increase heart rate and has no negative effects on the cardiovascular and central nervous system. However, be warned: There is insufficient clinical data at this time to either refute or validate these claims. Also keep in mind that Synephrine, one of the major ingredients in this product, is chemically related to Ephedrine, and it's therefore conceivable it may cause the same side effects as Ephedrine (i.e., increased risk of stroke, heart attack, rapid or irregular heart rate, and increased blood pressure).

As mentioned above, Nuphedrine contains the appetite suppressant Hoodia Gordonii. Although Hoodia is generally considered a safe and gentle supplement, note must be made about a potential safety concern: Preliminary research done by Pfizer apparently suggests Hoodia may have some unwanted effects on the liver, due to substances other than the active ingredient P57. (Unfortunately, the offending substances proved difficult to isolate from the Hoodia formula.) Of course, these results are just preliminary, and the final word on Hoodia is yet to be said. In the interim, it's up to each individual to decide whether the benefits of this product are worth the potential risks.

So Does It Work for Weight Loss?

This is a tough question to answer at this time. Reviewing the available information, I was struck by plenty of conflicting evidence. The manufacturer's site quotes clinical studies proving the efficacy of the product, however we haven't found reference to these studies elsewhere. Several independent review sites evaluating Nuphedrine give contradictory information - some praising the product beyond belief, while others label it useless.

I was also baffled by the fact that all websites which gave the product a positive review used pretty much the same language (canned phrases such as: "the most cutting-edge weight loss agent out thereā€¦", and the text of the reviews was reminiscent of an infomercial. This seems more than a bit suspicious, and leads us to believe the respective reviewers were not impartial.

True, the manufacturer's website shows many fairly impressive before and after customer pictures attesting to the efficacy of their drug. Other than that, however, we haven't found any independent customer testimonials regarding this product. As such, it's difficult to assess the true efficacy of Nuphedrine for weight loss at this time.


According to the instructions on the bottle, the recommended dose is 1 pill twice a day, 30 minutes before breakfast and lunch.


Nuphedrine is not available in stores as of the date of this review. It can be ordered online from the manufacturer's website. However, at $75 per box it's a pretty pricey product. A 60-day money back guarantee is offered if not entirely satisfied.


Please note: This product is for the use of adults only. Pregnant or nursing women should not take this product. Please be aware that any weight loss supplement may be associated with certain side effects and/or health risks. It is prudent to talk to your physician prior to using this or any other weight loss product, especially if you are taking other medication or suffer from a preexisting medical condition.

Disclaimer: Although the information on this page is correct to the best of our knowledge, its accuracy and completion are not guaranteed. Prior to using this or any other weight loss supplement, please refer to the instructions included by the manufacturer with the product purchased.

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